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Dec 30, - It is an integral part of a breast cancer screening program and helps in the early diagnosis Mammographic Guided Needle Wire Localization. The breast is then compressed as with a mammogram and a sequence of images is obtained to find the area of concern. Local anesthetic is then injected into your breast, and additional images are obtained to guide the biopsy. The radiologist inserts the needle into the breast and takes images of the area of concern.